LDN193189
1062368-24-4
Chemical Name
6-(2-(4-(2,4-DICHLOROPHENYL)-5-(4-METHYL-1H-IMIDAZOL-2-YL)PYRIMIDIN-2-YLAMINO)ETHYLAMINO)NICOTINONITRILE
MDL Number
MFCD11846251
Molecular Formula C22 H18 Cl2 N8
Molecular Weight 465.346
CAS Number
252917-06-9
Biological Activity:
A highly potent small molecule BMP
inhibitor; inhibiting BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30
nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation; useful
tool in stem cell biology.
LDN-193189 shows significant in vivo
clinical utility, inhibiting FOP and ectopic ossification and a potential agent
in the treatment of NSCLC lung tumors.
activebiopharma
+86 (0) 13336028439
+86 (0)571 81612335
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